The majority of heart attacks occur when there is a sudden rupture of atherosclerotic plaque, forming clots that can cause blockages of the arteries. But now, the diseased arteries can be treated with drugs delivered locally to vulnerable plaques by using the mathematical modelbased simulation and analysis of drug delivery process. The main objective of the development of this model was to produce a three dimensional mathematical simulation of coupled mass transport of drug and drug-encapsulated nanoparticles in the artery.
Mathematical model based Simulation is created that runs in a virtual patient-specific multi layered coronary artery wall segment and the drug deliver root and status can be analyzed using the model. The method observe the trends and data generated by simulation and demonstrates the potential for optimizing drug design parameters, including delivery location, nanoparticle surface properties, and drug release rate.
The mathematical model based findings provide a research framework for future work. An area to be addressed is an extension to deformable artery wall models. Incorporation of a bound drug model that will account for the specific and non-specific interactions of drug with binding sites such as proteins within the arterial tissue. In addition, a numerical sensitivity analysis can be performed to assess the potential importance of lateral driving force on drug distribution. Furthermore, the modular aspect of this computational tool allows incorporation of new functionalities fairly easily that can greatly facilitate design and optimization procedures.
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